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The study found that CRISPR-Gold's approach to Cas9 protein delivery is safer than viral delivery of CRISPR, which, in addition to toxicity, amplifies the side effects of Cas9 through continuous expression of this DNA-cutting enzyme.
In contrast to single cell migration, cells that migrate collectively retain their cell cell junctions through continuous expression of adhesion molecules.
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The use of viral vectors for gene delivery offer many advantages for both basic research and therapeutic application through the continuous expression of a gene product within a target region.
Through ex vivo NSC injection, continuous expression of the transduced genes in the brain microenvironment of WT and Mecp2tm1.1Bird+/− female mice was monitored and observed for 3 weeks.
However, in the course of progressive heart failure, the continuous expression of CTGF becomes enhanced through autocrine and paracrine regulation triggering an increased activation of prohypertrophic pathways like the Akt kinase pathway.
By contrast, embryos at 31.5°C displayed continuous expression of stress genes.
Third, the presence of U7 snRNA transgenes guarantees continuous expression.
Wnt1-induced tumors require continuous expression of Wnt1 [13].
Continuous expression of inflammatory cytokines such as IL-1β leads to continuous BBB leakage.
Specifically, the expressions for RTDs of molecules, fluid particles or any flowing entities passing through continuous flow systems have been derived from the stochastic population balance of these molecules, particles or entities.
But there's enormous opportunity through continuous incremental change.
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