Sentence examples for through blockade from inspiring English sources

Inhibition of APF through blockade of these channels would inhibit normal neuronal activity and directly contribute to cognitive dysfunction.

We show that host HSC clearance is dependent on Fc-mediated antibody effector functions, and enhancing effector activity through blockade of CD47, a myeloid-specific immune checkpoint, extends anti c-Kit conditioning to fully immunocompetent mice.

The results in toto indicate that the superior activity of the combi-molecule may be attributed to its ability to down-regulate DNA repair proteins such as XRCC1 and to alleviate anti-apoptotic signaling through blockade of EGFR-mediated signaling while inflicting high levels of DNA lesions to the cells.

Prevention of BAG3 degradation through blockade of caspase cleavage and subsequent ubiquitination results in cellular protection from STS-mediated apoptosis.

TLE prevented LPS-induced NF-κB activity both in IEC-18 cells and splenocytes through blockade of IκBα degradation, RelA nuclear translocation and transcriptional activity.

Through blockade of VEGFR2 signaling, r84 inhibits the migration of VEGFR2 positive endothelial cells, and blocks VEGFR2 phosphorylation and downstream signaling.

Apocynin is known to inhibit p47phox and p67phox translocation and superoxide formation through blockade of sulfhydryl groups thus interrupting the NADPH oxidase enzyme assembly [30].

Cocaine (Coopérative Pharmaceutique Française, France), a potent drug of abuse that produces its reward effects through blockade of brain dopamine transporters [49], was used as a pharmacological reward.

At 10 µM, BAPTA/AM reduced intracellular Ca2+ concentrations and prevented rMC-1 cell death induced by H2O2, similar to that of 1 µM SERPINA3K (Fig. 4F), suggesting that the protective effect of SERPINA3K is through blockade of the calcium overload induced by H2O2.

To test whether M-T7 inhibitory action is mediated through blockade of chemokine to heparan sulfate GAG binding, we examined WT (C57Bl/6 background, Ndst1+/+) donor to WT Balb/c recipient aortic allograft transplants and Ndst1−/− donor to WT Balb/c recipient mouse aortic allograft transplants, with and without treatment with M-T7 (Table 1, n = 74).

Considering these differences in the pathogenesis of Salmonella and extracellular Gram-negative infections, one would envisage either beneficial effects of lipoproteins on the host resistance to Salmonella through blockade of cellular internalization, or deleterious effects by blocking the induction of cytokines by Salmonella LPS that are required for the activation of host defense.