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Mechanistically, Mll3 deletion enhanced stem cell activity through activation of the HIF pathway.
Insulin and other growth factors repress FoxO1 activity through activation of the phosphoinositide 3-kinase-Akt/SGK signaling pathway causing FoxO1 phosphorylation, for instance, on Ser319.
Extracellular ATP induces macrophage bactericidal activity through activation of the purinergic P2X7 receptor.
This suggests that SWT may have the cancer preventive activity through activation of the Nrf2 pathway.
CSMD1 expresses mainly in epithelial cells and exhibits anti-tumor activity through activation of the Smad pathway [ 42, 43].
Src could downregulate caspase-8 activity either directly or through activation of the p38-mitogen-activated protein kinase pathway.
Furthermore, different cancer cells lacking Scd1 activity reduce de novo lipogenesis through activation of the AMPK pathway [22], [24].
NCKX4 activity was stimulated by ATP through activation of the P2Y receptor signalling pathway.
LIF maintains mESC self-renewal through activation of the signal transducer and activator of transcription 3 (Stat3).
Huang, G. L. et al. Oncogenic activity of retinoic acid receptor gamma is exhibited through activation of the Akt/NF-kappaB and Wnt/β-catenin pathways in cholangiocarcinoma.
Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3.
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