Hence, deoxygedunin imitates BDNF's biological activities through activating TrkB, providing a powerful therapeutic tool for treatment of various neurological diseases.
Therefore, PA might induce autophagy activation through activating PKCα pathway in hepatocytes.
Activation is also aided by the integration of activation signals through activating receptors on the cells.
Flavonoids Naringenin and hesperetin might exert anti-atherogenic effects partly through activating peroxisome proliferator-activated receptor and up-regulating adiponectin expression in adipocytes [100].
IFIT2 has been reported to be a tumor suppressor via mediating cell apoptosis through activating caspase-3/7 activity.
Constitutive activation of Ras through activating mutations, such as RasV12, leads to oncogenic transformation of immortalized mouse fibroblasts [ 26].
Rac1 activation has been reported to induce apoptosis through activating the JNK pathway.
These results suggest that activation of TRPV1 by capsaicin induces autophagy through activating AMPK signaling pathway.
The active extracts and constituents of TT could improve sexual function through activating aphrodisiacs and improving fertility in men.
By contrast, inhibitory FcγR regulate immune responses by inhibiting the activation of B lymphocytes, monocytes, mast cells and basophils, induced through activating receptors.
Through activating AhR, PAHs induce CYP1B1 expression and in turn promote their own activation into carcinogens.
