Sentence examples for through a substitution from inspiring English sources

The enzyme coding region contains a well-investigated single-nucleotide-polymorphism (SNP) in codon 158 (rs4680), in which valine (Val) is substituted to methionine (Met) through a substitution of guanine to adenine.

Further, if the fiber surface consists of SiC or any silicon-containing compound, the BF3 gas reacts through a substitution of the silicon by boron in the initial fiber composition.

Here we show that changing the charge of the ψεRACK peptide through a substitution of only one amino acid (aspartate to asparagine) resulted in a peptide with an opposite activity on the same cell function and a substitution for aspartate with an alanine resulted in an inactive peptide.

For example, improving access to and the quality of public transportation in neighborhoods far from the city core could make these neighborhoods more competitive with more expensive, downtown neighborhoods and so could relieve some price pressure in downtown neighborhoods through a substitution effect.

Moreover, one mutation that differentiates the 1988 isolates from the 2000 isolates occurred in the tRNA prophage (possibly through a substitution or due to a recombination event).

Hickman and Rusche [ 60] studied the duplicated histone deacetylases Sir2p and Hst1p in S. cerevisiae and found that these paralogs with non-overlapping functions could confer genetic robustness against null mutations through a substitution mechanism.

The probe is designed in such a way that the intramolecular charge transfer (ICT) of the 4-hydroxynaphthalimide was masked by the 4-bromobutyrate moiety, and the selective deprotection of the 4-bromobutyrate group of the probe by hydrazine through a substitution-cyclisation-elimination process results in the recovery of the ICT of 4-hydroxynaphthalimide.

The frozen cells were substituted through a freeze-substitution-solution (0.1% glutaraldehyde, 0.2% uranyl acetate and 1% water in acetone) and stepwise infiltrated with Lowicryl HM20 (Polysciences, Inc., Warrington, PA).

In this paper, a novel electrically-conductive and biodegradable polyphosphazene polymer containing parent aniline pentamer (PAP) and glycine ethyl ester (GEE) as side chains was synthesized through a nucleophilic substitution reaction for its potential application in nerve regeneration.

These Cp-Fe-CNCs were next monolithiated by sec-butyllithium and went through a nucleophilic substitution reaction with PCMS, thus forming successfully a PCMC CNC nanocomposite with all CNCs covalently bonded to PCMS.

2,4-dinitrofluorobenzene (DNFB) as an active aryl halide reacts with primary or secondary amine in aqueous alkaline medium to form a yellow colored product through a nucleophilic substitution reaction [33].