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The results reported in this study concluded that local high PIP2 achieved through a sequestration mechanism could provide sufficient IP3 for supralinear calcium release.
Biofilm formation in P. fluorescens as a response to nutritional cues relies on the lap operon, which contains genes encoding the signal-integrating transmembrane protein LapD, a c-di-GMP receptor that regulates periplasmic proteolysis through a sequestration of the protease LapG.
Specifically, through a sequestration mechanism that is yet to be characterized at the molecular level, E proteins are locked into ectopic SCL core complexes that act by repressing apoptotic pathways and preventing the normal T cell transcriptional program (Herblot et al., 2000; Palii et al., 2011; Sanda et al., 2012).
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This could happen through an efficient sequestration of T C by another molecule which is produced at a rate β and is degraded at a comparatively low rate for t r ≤ t ≤ t day.
CSH has been working with our partners nationally and in the field to reverse budget caps and cuts imposed by our federal leaders through a process called sequestration (forced confiscation of funds).
Leggett said he regards as one of his proudest accomplishments keeping the county on a steady financial footing through recession and sequestration — a program of automatic cuts to federal government spending.
The most straightforward interpretation of these results is that excess cytoplasmic hBora interferes with bipolar spindle formation through the sequestration of Aurora A away from the spindle.
Nonetheless, taken together, our findings demonstrate that protein blockade, transcriptional silencing, or genomic ablation of sFLT-1 can induce CNV/RAP, showing that sFLT-1, through sequestration of VEGF-A, is a key molecular defender of vision-critical photoreceptor avascular privilege.
PTRN-1 could itself be a part of the machinery that represses the DLK-1 pathway, or it could be acting indirectly through the sequestration of a remodeling sensor.
Although the gene encoding p27 is rarely mutated in human cancers, p27 is functionally inactivated in a majority of human cancers through accelerated p27 proteolysis, through sequestration by cyclin D cyclin-dependent kinase complexes anD cyclin-dependentislocalization.
Whether through sequestration or a fiscal deal, with the war in Afghanistan coming to a close and no existential threat on the horizon, military spending in the grand scheme of the government, is becoming a sideshow.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com