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We compute the data energy by converting the z-score to a value U d (x i) at nucleotide i according to (8) where d z (x i) = z – score(region(x i)) – w n × z – score neigbor(x i)) and zmin and zmax are, respectively, parameters for the minimum and maximum thresholds of z-score.
Conjunction analysis was performed with a height threshold of Z = 3.3 and a cluster threshold of p = 0.001 (corrected).
Group-level statistics were thresholded with a height threshold of Z = 2.3 and a cluster extent threshold of p = 0.05 (corrected).
We used a cluster-extent approach with a height threshold of Z = 3.09 and a cluster threshold of p = 0.001 (corrected).
Assuming the normality of Prand(S), we use the z-score to compute the significance of the real data with the threshold of z ≥ 1.6 for modules to be larger than expected by chance.
Green = concordance with surgery localization, red = different region, and orange = non-localizing at threshold of z = 1.5 SD and z = 2 SD.
b The images at threshold of z = 2 show a clear focal hyperperfusion in the left occipital lobe with propagation towards the contralateral occipital lobe.
a The images at threshold of z = 1.5 show a widespread hyperperfusion in both occipital cortices but also a significant cluster in the right temporal lobe which was interpreted as the ictal onset zone with propagation to both occipital cortices.
Weighted contrasts for all effects of interest were assessed with an initial Z-value threshold of Z = 2.33, p≤.01, and whole brain cluster corrected to p≤.05.
The maps corresponding to positive activation from each b-factor were examined and those voxels producing activation above a statistical threshold of z = 4 in all three maps were analyzed.
We chose a threshold of Z > 0.77 and Z > 1.1 for Ndt80 and Sum1, respectively.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com