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One of our recent publications has demonstrated how methods such as HRS could potentially be used to examine more subtle thresholds of tissue injury than just examining core versus penumbra (Supplementary Figure 3 in Ghosh et al., 2012).
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A cutoff threshold of tissue TF pairs common in at least 50% tissues from the same group was set up for searching tissue-type TF pairs.
As the ABR has widespread clinical use, we evaluated the ability of this electrophysiological method to characterize the threshold of tissue ID in rats by examining the relationship between markers of tissue ID and severity of ABR latency defects.
Future research is necessary to confirm whether or not there is a baseline threshold of tissue IL-10 mRNA expression that will identify individual patients with early RA who are more likely to demonstrate an aggressive disease course.
Furthermore, tDCS has not been reported to provoke seizures in non-acute neurological deficits, i.e., intervention protocols are well below the threshold of tissue damage (Liebetanz et al., 2009; Nitsche, Schauenburg, et al., 2003).
As our two previous studies and additional published reports from others are not directly comparable due to different rat strains and diets, the goal of the present study was hence to determine whether the ABR could be utilized to detect the threshold of tissue ID in offspring exposed to lifetime ID ranging from mild to severe.
To improve our understanding of the TMJ function in normal and pathological situations, accurate and validated three-dimensional (3-D) finite element models (FEMs) of the human TMJ may serve as valuable diagnostic tools as well as predictors of thresholds for tissue damage resulting from parafunctional activities and trauma.
These different phenotypes may be considered as an example of the different respiratory thresholds of different tissues (42).
In order to make use of the inherently low energy of NIR light, these mechanisms all require simultaneous two-photon absorption, necessitating the use of high-powered and focused pulsed NIR lasers, with energies sometimes exceeding the damage threshold of biological tissue.
As described in the Background, coverage of the entire target area with fields above reversible threshold is very important for successful ECT, and above irreversible threshold for ablation of tissue by NTIRE.
This and the threshold for tissue uptake of HB-19 could prevent prolonged accumulation of HB-19 in vivo, which otherwise would lead to toxic effects [ 15].
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