That is, in contrast to previous work, we find a linear proportionality only above a certain threshold of population, a slope 0.929 955% CI of 0.85-1.01), belowelow that threshold the fit and the trend substantially weaken to only 0.18 (95% CI of 0.17-0.20).
Criterion A measures extinction risk based on exceeding a threshold of population decline (30% for Vulnerable, 50% for Endangered, and 80% for Critically Endangered) over a timeframe of three generation lengths, a measure of reproductive turnover rate, in the recent past.
Nationally, CL incidence was associated with the level of migrants in 'isolated' communes, more markedly above a given threshold of population density.
Sir, We thank Professor Wakeford for his comments on our recent paper, which evidenced an increased risk of childhood acute leukaemia in isolated French communes that were subject to highest inter-census population movements, more markedly above a given threshold of population density (Bellec et al, 2008).
Previous disclosures for research purposes, for example of cancer registry data, have deemed thresholds of 5%and20%0% population uniqueness as acceptable thresholds to use for research data [ 51- 53].
Specifically, previous disclosures of cancer registry data have deemed thresholds of 5%and20%0% population uniqueness as acceptable for public release and research use respectively [ 38- 40].
Future studies of the urban rural association should explore the importance of a dose response effect, a threshold value of population size, and population density.
So although it appears that the threshold level of population immunity required to drive antigenic drift has not yet been reached, we might expect antigenic variants to emerge over the next year or so as the pool of susceptible individuals declines.
Furthermore, additional studies are need to evaluate whether the following factors affect the risk of developing IBD: increasing population size (i.e. a dose response effect); a threshold value of population size; the number of people living per unit area (i.e. population density); and the duration and timing of exposure.
