The limited scope of the norms renders the equality of obligations during NIAC less meaningful, particularly in situations where the high threshold for application of Additional Protocol II is not met.
The comparative method developed here may be useful for testing other proposed alert thresholds and for application in other populations.
In order to do this, we optimized the CNV detection thresholds for clinical application, and interpreted all de novo CNV calls, as well as regions of homozygosity that could be of clinical interest.
Furthermore, a systematic investigation of the impact of the different thresholds used here, including thresholds on posterior probabilities and size of CMBs, would help in optimizing the thresholds for specific applications more objectively.
Consequently, this approach generates a table of estimated recall and precision values from which it becomes possible to determine the appropriate similarity threshold for the application.
In addition, the threshold for the application of hate speech provisions may also be too high (e.g. the incitement of hatred or discrimination) to realistic engage the types of harm that can be produced by crisis communication.
Different cohort sample sizes between investigations also make it important to calculate the delta threshold for each application of the CHC method.
Our decision to apply a low predicted risk threshold for the application of the model clearly defines this as a means to predict low risk of AHFS hospitalisation, and the negative predictive value (99.1% and 100% in derivation and validation cohorts) means that <1% of 'low risk' patients will experience AHFS hospitalisation.
The comparative technique developed in this study may be useful for testing other proposed alert threshold methods and for application in other populations and other diseases.
Further optimization of sequence similarity thresholds for public health applications will be necessary to ensure proper interpretation of the index.
