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In presence of the above mentioned "red flags", low thresholds for additional diagnostic procedures are justified.
EMSA thresholds for additional models were selected as described above (see Results section "Experimental verification of predicted FoxA binding sites by EMSA").
Based on conventional willingness to pay thresholds for additional QALYs (approximately £20 000 per QALY), 38 the incremental cost to utility ratio of £463 (£26.41/0.057 QALYs) in the high-risk group demonstrates that the additional health benefits are worth the additional cost.
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Mr. Bernanke has been clear about the threshold for additional action, telling Congress the decision hinged on whether the Fed expected the economy to grow fast enough to reduce unemployment, as inflation remains firmly in check.
4.5 In general, if a headache is probable or atypical according to ICHD-3-b the threshold for additional investigations should be lower.
These dynamic and time-dependent processes could also influence the threshold for additional cell damage over time.
Additional bacterial infection can complicate TB-related ICU admissions [ 8] and a low threshold for additional anti-bactericidal therapy should be present.
Hence we believe a low threshold for additional imaging, such as a magnetic resonance imaging, should be considered for patients with HME with subacromial impingement syndrome to ensure a symptomatic exostosis is not neglected.
Higher case fatality and more frequent complications warrant more intense monitoring and a low threshold for additional investigations to diagnose concomitant invasive bacterial infections, including chest X-ray, blood culture, and lumbar puncture with CSF examination.
While it is clear that HIV and aging each contribute independent deleterious effects on the CNS, resulting in decreased cognitive functioning in a subset of individuals, indirect lines of evidence have also suggested that HIV might lower the threshold for additional neurodegenerative processes that are usually seen at a later age outside of the context of HIV.
After correcting for the false mutation proportion, we explored mutation calling using three different thresholds for optimization (Additional file 1: Table S1).
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