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The loss of SirT1 therefore increased the basal level of both IGFBP-1 and IκBα in multilineages of cells, and potentially increased thresholds for activating SirT1-modulated signaling pathways.
We found a uniform proportion of S/G2 cells across all bins indicating that cells in different cell cycle phases do not differ in their thresholds for activating a p53 pulse.
Drosophila Pain and Pyr function as thermosensors responding to different "hot" temperatures (The temperature thresholds for activating Pain and Pyr are 42.6 and 37.5-40°C 37.5-40°Cvely) [ 8, 10, 35], and Drespectivelyrw functions as a moist receptor for hygrosensation [ 14].
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Thus our data and model sensitivity support the concept that the observed oscillatory autoimmune response could be explained by a decrease in the strength of the Teff-Treg cross-regulation, a combination of increasing the Teff threshold for activating Treg cells and reducing the number of activated Treg cells.
With this type of approach, the threshold for activating individual primary sensory afferents is in the order of 0.2 mA21,51.
The board decided to lower the threshold for activating a so-called poison pill after other companies lowered theirs, Ms. Collier said.
The threshold for bundle activation varied across electrodes and retinas, and was in the same range as the threshold for activating retinal ganglion cells near their somas.
The feasibility of exceeding the typical ∼10 mV depolarization threshold for activating the action potentials is examined.
Here we report that oscillations reduce the effective Ca2+ threshold for activating transcription factors, thereby increasing signal detection at low levels of stimulation.
In seven of eight dogs, VNS-evoked bradycardia (defined as ≥10% decrease in heart rate) was achieved by applying stimuli at amplitudes equal to or greater than the threshold for activating slow B-fibers.
Stimulus strength was set at 50% above threshold for activating the C fiber of interest.
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CEO of Professional Science Editing for Scientists @ prosciediting.com