Sentence examples for thresholds activation of from inspiring English sources

The withdrawal state is associated with raised reward thresholds, activation of stress systems in the amygdala and the development of hedonic allostasis – a pathological alteration in the set point of a hedonically positive, or at best neutral, state that an individual dependent on drugs persistently seeks but fails to achieve through repeated drug taking (Koob, 1996, 2008).

Importantly, we reveal novel findings on the mechanism of threshold activation of p53 pulsatile and oscillatory dynamics that are important for its physiological function as the guardian of the genome.

Our results show that the p53 spontaneous pulses are due to intrinsic DNA double strand breaks in normal proliferating cells, and p53 auto-regulation (positive feedback loop) allows threshold activation of p53 in generating these pulses.

Therefore there may be threshold activation of some signals that are important to the cell, well before they become observable using Western blot analysis.

The threshold activation of STAT3 in some ovarian cancer cell lines depended on the endogenous level of phosphorylated STAT3.

Both the propentofylline treatment and the monoarthritic condition modified the stimulating current required for threshold activation of C reflex responses.

In all animals the experiments began with the measurement of the current required for threshold activation of the C-reflex in each of four groups of animals.

The stimulating current required for threshold activation of the C-reflex in each of four groups of animals is shown in Table 1.

Once stable C-reflex responses were obtained, the stimulus strength was lowered and the current required for threshold activation of the C-reflex determined.

However, there was no suprathreshold or sub-threshold activation of contralateral M1 and S1 hand area (Supplementary Table S1, Fig. 3).

Two-way analysis of variance (ANOVA) identified the propentofylline treatment (P ANOVA < 0.0001, F = 25.79) and the monoarthritic condition (P = 0.0065, F = 8.64) as significant factors influencing the stimulating current required for threshold activation of the C-reflex.