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While this threshold performed best for the overall group of 30 patients, in individual patients, this was true in only 11 cases.
The 60-day threshold performed similarly well, with only a marginal difference (<0.1%) in misclassification.
For the data generating processes 4 and 5 Bayesian model averaging with 50% threshold performed best, followed by Stepwise regression.
Bayesian model averaging with 50% posterior probability threshold performed similar to stepwise regression in selecting a true predictor.
By comparison the same threshold performed far worse in the N0 sub-group with a sensitivity of only 16% although the high specificity was maintained.
When we examined autozygosity arising from common ancestors within the past 20 generations, a 45 to 50 SNP minimum threshold performed best when using moderate LD-pruning, depending on how much error is expected in the SNP data.
Similar(53)
The non-linear BER threshold performs slightly worse than the linear BER threshold in the whole SNR region.
Under moderate to high load, the dynamic threshold performs better than the highest fixed threshold, but worse than the lower ones.
Even the constant threshold performs well, if it is signed.
On the contrary, we were not able to identify any threshold performing the analysis on BM-WT1 levels.
This means that for variants meeting this threshold, performing Sanger sequencing is non-informative beyond sample QC, as the vast majority of results will be concordant and the remaining negative results will not be interpretable.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com