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The significance threshold (p) was set below 0.05 (MudPIT scoring).
In this study, we controlled the statistical artifact of multiple comparisons (type II error) by choosing a very conservative significance threshold (p < 0.000001).
Applying Samocha's model to our exome data revealed that, unlike OA, there were significant mutations in RA (conservative significance threshold (P = 1 × 10−8)) (Fig. 6a).
We collected a list of the variants identified by the GWAS conducted for the Japanese population that satisfied the typical genome-wide significance threshold (P < 5.0 × 10−8).
A uniform threshold (P = 1/n, n is the effective number of independent SNPs) was used as the genome-wide significance threshold for all three panels.
No hippocampal activation was found, even at a liberal threshold (p = 0.01, uncorrected).
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Fisher's exact tests were implemented at a threshold p-value of 0.05.
In total, we identified 129 different TF binding motifs in the roughly 110,000 OCRs tested, using a threshold p-value of <1e-50.
The red line represents the significance threshold (p-value = 0.05).
Differentially expressed genes have been selected based on a threshold p-value of 10−4.
The false discovery rate (FDR) was used to determine the threshold P-value in multiple tests.
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