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At a positivity threshold ≥ 1, sensitivity of CCA POC for S. mansoni was lower (72% vs 89%) and specificity higher (85% vs 55%) than at a positivity threshold of trace positive.
Using microscopy only (KK) as the reference standard, our review, which incorporated all include study results along with findings of additional studies, produced a comparable summary estimate of 89% sensitivity but a lower summary estimate of 55% specificity at a threshold of trace positive.
Tests for S. mansoni Compared to microscopy, the CCA test meta-analytic estimates for detecting S. mansoni at a single threshold of trace positive were: sensitivity 89% (95% CI 86% to 92%); and specificity 55%95%CI46%to65%to 65%; 15 studies, 6091 participants) Against a higher quality reference standard, the sensitivity results were comparable (89% vs 88%) but specificity was higher (66% vs 55%).
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Some studies (n = 2) provided data points at both thresholds of trace and +1.
During pre-assembly, sequencing ends were trimmed using a medium-stringency criteria, with the following SeqMan parameters: average quality score Q/n threshold of 12, a non-trace window size of 50, and a maximum of 2 Ns.
Meta-analytical sensitivity and specificity (95% CI) of data at a threshold ≥ trace positive were 89%86%to92o 92%) and 55%46%to65o 65%) (figure 12).
An arbitrary threshold of ±0.15 Kendall tau is traced by the dashed lines parallel to the main diagonal.
With this aim in mind, the unitigger error rate, which specifies the threshold of similarity at which two traces are assembled, was adjusted over a range of values.
A simulation study of the relationship between the threshold of ERD/ERS of artificial EEG traces and the QPs is also provided.
Because of the uncertainty regarding threshold doses and the resulting qualitative regulatory strategy, food manufacturers tend to declare the presence of trace amounts, or even possible trace amounts on the label.
We considered as connected pairs those showing both PSCs detected in averaged traces with a threshold of 2 times the standard deviation of the noise and an increased occurrence probability of individual PSCs within 100 ms after photostimulation when visualized in raster plots.
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