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The concentrations chosen encompass the physiological (10 μM), threshold of toxicity (100 μM), and toxic (1,000 μM) spectrum based on reports by Suzuki et al. [ 28] performed in monkeys.
One washed-up orca, given the name Lulu by researchers, was found to have 957mg/kg of PCBs accumulated in lipid tissue, a level 100 times above the threshold of toxicity.
Thus, the threshold of toxicity might be patient-dependent.
The threshold of toxicity is usually determined based on tests of dose-response relationships related to a single chemical.
Taken together, these data confirm that age likely modulates Fe3O4 nanoparticles liver toxicity and one might propose that a threshold of toxicity might play a key role.
No threshold of toxicity has been defined currently, however TDM could aid early recognition of potential drug-related toxicities (especially neurological toxicity) in susceptible patients [ 44– 44].
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The explanation for this might be pretty simple, because DA levels have to be maintained at very defined levels and must not exceed thresholds of toxicity.
In combination synergism was observed reducing the threshold values of toxicity to 4 10 μM, and aromatase activity by 50% in some cases.
Because the threshold levels of toxicity for the different OHCs are unknown, we did not statistically test low versus high levels of OHCs in relation to outcome.
The threshold range of toxicity, where reduced productivity was evident in wood ducks (based on TCDD-EQs), was > 20 to 50 ppt.
Studies from animal models indicate that CPF is a developmental neurotoxicant able to target immature central nervous system at dose levels well below the threshold of systemic toxicity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com