By implementing this M eff _ G, it would be easy to replace the actual number of SNPs m to by the effective number of SNPs M eff _ G in our algorithm step 1. Correspondingly, the adjusted PWER is α p = α e / M eff _ G, leading to a less conservative threshold of point-wise significance and in turn a relatively small number of permutation times.
The performance of the e-model by different point thresholds for the identification of diabetes corroborated using a threshold of 1 point to optimize sensitivity and specificity.
The rate of insertion time of more than 10minwas 12.4%, 21.1%, 35.4%, 47.4%, 60.0%, 66.7% respectively, p < 0.001 (Table 4 .. Next, we performed a ROC curve, the area under the ROC for predicting difficult colonoscopy (insertion time more than 10 min) was 0.66, with an optimal threshold of 1 point (Additional file 2: Figure S2).
The best fitting rate model, maximum shift points and the threshold of shift points were estimated according to the maximum log-likelihood values using Akaike Information Criterion AICC) weights and Delta-AIC scores [ 55].
For the 2 SD threshold 5% of points will exceed the threshold.
A threshold of 38 points at 12 months and 11-point change in Oxford Hip Score or 14-point change in Oxford Knee Score (from preoperative score) is suggested as being predictive of satisfaction.
The question of which of these two values should be used as a threshold to indicate distinct cancer suspicion was discussed with our clinicians, who clearly favored the threshold of ≥10 points for its very high sensitivity level of 90% with an acceptable specificity level of 62%.
Because of reliability issues, we used a threshold of 10 points.
A threshold of 3 points has been proposed to demonstrate a clinically important difference (Murray et al. 2007).
Untreated hemophilic mice essentially never score less than this threshold of 2 points out of 10, whereas the historic mean is ∼4.4 out of 10 for hemophilic mice.
Both between group differences in SGRQ scores will be assessed as well as the proportion of patients crossing the clinical relevant threshold of 4 points [ 24].
