While 57 genes had a positive score below the significance threshold of 3.67 indicating relevance with respect to specific experiments only, 121 genes had a score near zero indicating that dosage effects were either compensated or not detected with the selected experimental data.
In all cases the CR was above the minimum threshold of 0.70 [28], indicating we have reliability in our constructs.
The FFAS03 structural alignment score for the ZIP10 PL domain (murine ZIP10 residues 285 395 achieved statistical significance for an alignment with the structure of Xenopus laevis PrP (PDB entry: 1xu0) [25] with a value of −9.6 (and a threshold of −9.5 indicating less than 3% false positives).
The treatment decision in the DAS28-driven group depended on a threshold of 3.2, indicating LDA.
All item-total correlations corrected for overlap were higher than the threshold of 0.40, indicating good construct validity.
Protein hits were taken as identified if the mascot score exceeded the threshold of P<0.05, indicating identification at the 95% confidence level.
However, the set of marker genes is still over expressed in the positive SNs and the discriminant scores of all 19 SN are above the threshold of zero, indicating the presence of metastatic breast tumour cells.
The CAR model also successfully converged, as the maximum Monte Carlo SE was 0.028 (which was below our threshold of 0.1), indicating that a sufficient number of posterior samples were generated for the estimates to stabilise.
It showed that the reliability was 0.85, which was close to the threshold of 0.90, indicating the potential use of EQ-5D-5L for measuring HRQOL at an individual level.
After 35,000,000 generations, all effective sample size (ESS) values for the divergence time analysis (as viewed in Tracer) were well above the recommended threshold of 200, indicating that parameter space had been sufficiently sampled.
