It also provides an indicative threshold of vaccine efficacy, which could guide future development.
In nearly 60%% of patients, including over 30%% of patients with fully functional CYP2D6, (Z -endoxifen concentration was below the predefined threshold of therapeutic efficacy.
Under such circumstances, each patient has an individual threshold of respiratory efficacy, reflected by the VT/EAdi ratio, corresponding to the idea of a "fatigue zone" from the work of Tobin [ 28].
22 Since lower dosages are often prescribed at the initiation of a treatment and thus could decrease the overall daily dosage, we used the lower range of what is considered the minimum threshold of pharmacological efficacy.
Clozapine, the prototypical representative of this group, does not reach even at very high doses the 70% of D2 receptor occupancy, considered to be the threshold of therapeutic efficacy for classical antipsychotics (Nordstrom et al. 1998; Kapur et al. 1999; Nyberg et al. 1999).
The identification of an area under the curve/minimum inhibitory concentration threshold for efficacy in animal models of pneumococcal infection was confirmed in clinical studies of treatment of patients with community-acquired respiratory tract infections for five different members of the class.
Namely, that even 100% bednet coverage is not necessarily sufficient to prevent malaria's persistence and that incorporating this imperfection of bednet coverage necessitates a stricter threshold of mosquito-killing efficacy to drive R0 below unity.
Future investigations will require combination of vitespen with immunostimulatory or targeted agents that may permit this agent to reach the threshold of consistent clinical efficacy in the metastatic setting.
We defined the MIC as the concentration that inhibits the growth of 90% of important relevant infectious pathogens (MIC90) (particularly S. aureus and Enterococcus species) [ 47, 48] and therefore, we set the threshold of potential therapeutic efficacy of Cmin at 2 mg/L.
Collectively, our data indicate a trend favoring time over threshold and exposure over threshold as most important determinants of efficacy for KAE609 rather than the concentration over threshold.
