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Also, a possible confounding effect associated with the vehicle used to deliver masitinib or imatinib dimethyl sulphoxide (DMSO) can be excluded because the concentration used was below the threshold of effect.
Another possible disadvantage would have been the dilution of the aetiological agent below a threshold of effect.
As far as we can tell, at a population level, there is no threshold of effect for the effects of the ambient aerosol.
So, if we accept that there is a threshold of effect then at exposures below that threshold potassium cyanide is not a hazard.
Such findings suggest that the decrease in birth weight per 1-μg/dL increase in PbB was greater at lower concentrations than at higher concentrations without evidence of a lower threshold of effect.
There appears to be an ameliorating effect of low baseline HCV RNA on the influence of baseline NS5A polymorphisms at L31 and/or Y93H on sustained response to DCV + ASV, but it is a limitation of the study that the number of patients with low HCV RNA and these polymorphisms is too low to establish a robust threshold of effect for clinical decision making.
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Moreover, metabolomics changes were below the threshold of effects.
Categorical dose response analyses were performed to discern potential patterns or thresholds of effect.
This allows both the researchers and readers to look for possible thresholds of effect and the OR corresponding to the cutoffs that they are interested in.
The effects with which we are concerned are, in general, not those associated with effects on the genetic material of cells but are effects on the cardiovascular and respiratory systems: effects that are usually thought to be characterised by thresholds of effect.
This approach to risk assessment depends on the use of appropriate and sensitive endpoints, and on valid assumptions for extrapolation estimates (e.g. dose-response linearity) and calculations, and on the existence of thresholds of effects (15 17).
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