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(H) Threshold of action potential in DRG neurons before and after BmK I treatment (BmK I: n = 6; control: n = 8; **P < 0.05).
In addition, the threshold of action potential was also significantly raised from −39.2±0.5 to −34.7±1.2 mV (P<0.01, paired t test, Fig. 7D).
The depolarization never led to spontaneous firing of the recorded neuron even when the resting membrane potential was set to a level close to the threshold of action potential firing by injecting steady depolarizing current.
7A, 7B) of action potentials evoked by depolarizing current pulses, prolonged the latency of the first spike (Fig. 6C) and increased the rheobase current (Fig. 6D) as well as the threshold of action potential firing (Fig. 7D).
We used 30 nM TTX as a comparator because it approximated the increased threshold of action potentials and decreased excitability observed with the intermediate concentration of Mg++.
Resting membrane potential, input conductance, current injection to threshold of action potential firing, capacitance, and membrane time constant were unaffected by time of day or the absence of BMAL1.
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As we have shown, the two approaches converge whether one assumes a threshold mode of action (Krogh et al. 1974 pig study and modified uncertainty factors), or a non-threshold mode of action (NTP 1989 rat study), with both leading to a TDI or NCRI in the order of 4ngkgbw−1 per day.
For nonlinear extrapolation resulting in a RfD (which the U.S. EPA uses for non-cancer effects and carcinogens with a threshold mode of action), Sand et al. (2011) chose to linearly extrapolate to a 1/1,000 risk in the test animal, which they considered analogous to applying a 100-fold uncertainty factor to a BMDL10 (lower bound on the benchmark dose corresponding to 10% extra risk).
A series of EPPs, or a number of them stimulated simultaneously at many synapses, can then bring the cell to the threshold of the action potential.
Although objective bases to explain these ethnic differences are still insufficient, some investigators insist that the differences are related to a difference in the threshold of physiological action of hormones affecting vitamin D metabolism [ 9].
The gross- and histo-pathological aspects of the OTA-induced tumours point to a non-threshold mode of action (Table 1).
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limit of action
stage of action
criteria of action
threshold of taking
threshold of greatness
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threshold of something
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threshold of risk
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Justyna Jupowicz-Kozak
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