For the threshold of solvent accessibility, we used a cut-off of 7.0% relative total side-chain accessibility.
It implies that C2 crosses a new threshold of C4 accessibility, and that C4 is all but an inevitable outcome.
For a relative accessibility threshold of 25%, only 46.1% of PPIIDSSP are buried while in the case of turns, β-strands, α-helices and coils, 35.8%, 72.2%, 55.4% and 51.9% of residues are buried, respectively.
A solvent accessibility threshold of 25% was used for classifying residues as exposed or buried.
To evaluate the influence of the available data in a work position, we used a Q2 index in a two state model with a classical relative solvent accessibility threshold of 16%. Figure S2 shows that, as expected, the level of good predictions increases with the occupancy of a work position and is quite satisfying above 8to1010 members per work position.
It is known that the lipid composition determines the cholesterol-accessibility threshold of a membrane, and previous studies have shown that the lipid composition influences the magnitude of any oxysterol membrane disordering effects (i.e., 25-HC has stronger membrane disordering effects in unsaturated vs saturated lipid environments).
Statistical analysis of trip length forms the basis of an adaptive threshold for the calculation of a cumulative potential measure of accessibility.
Using the same definition of work positions (10, 80%%) and a three-state model with classical 9% and 36% thresholds of relative solvent accessibility, a similar process leads to a Q3 of 65 good predictions.
Besides having the aforementioned up side of accessibility, professional caregivers see a down side to teleconsultation, which lowers thresholds too much and increases their workload.
The effect of this threshold on the accessibility index is small, however.
