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Second, identifying a threshold in the human population is confounded because not all people are equally sensitive to the effects of a chemical; there would be a graded response to a chemical thereby obscuring the observation of a threshold, if there is one.
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As results were consistent across thresholds a value of 75% was used, in keeping with the chosen threshold in the seminal human rich club report (van den Heuvel and Sporns, 2011).
This threshold corroborates the threshold commonly used in the human clinic, but could certainly be discussed in the context of a dog population, particularly as the human threshold was chosen as the depth at which tooth brush bristles can no longer reach sufficiently into the pocket to clean the teeth.
As we were interested in the discrimination threshold of the human participants, we told the study participants that they would have to choose the larger of two cubes in the subsequent test conditions, but reported no further details of the testing procedure.
The critical difference between the MIAPri and the classic IAP near the ACS threshold in our mathematical modelling, as well as the significantly higher MIAPri than the IAPee around the IAH threshold in our human study, calls for future studies.
If absolute zero-effect threshold cannot be demonstrated in the human population, we do not concur that the combined effect(s) of chemicals with independent modes-of-action below levels derived to be 'safe' for single substances should be assumed to be negligible.
The threshold of the human capital level is explicitly given in the appendix.
Although STMN2 did not reach the threshold for genome-wide significance in the human vCJD GWAS study, supporting evidence was provided from replication in the acquired prion disease from Papua New Guinea, kuru [6].
These results are consistent with previous reports indicating that tPA −/− mice are seizure resistant, 14, 15 that neuronal overexpression of tPA in mice leads to a lower seizure threshold, 16 and that mutations in the human neuroserpin gene are associated with epilepsy.
We regard that both these density dependences are likely to independently and simultaneously act to affect the transmission of filariasis, via the introduction of vector biting transmission thresholds and breakpoint worm levels in the human population [10].
Low threshold unmyelinated mechanoafferents (C tactile, CT) in the human hairy skin have recently been linked to pleasant touch sensation.
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