4) Provide a clearer justification of your threshold for functionality.
Although our last exclusion criteria defined a low threshold for functionality to be enrolled in the trial, none of the study participants was unable to perform the lower extremity tests defined in the protocol.
By strongly increasing the protein's affinity for many REs, replacement glu25GLY moved the evolving AncSR-DBD well above the threshold for functionality, allowing the protein to tolerate other replacements that refined the protein's specificity while decreasing its generic RE affinity.
Results are presented on basic functionality, threshold dispersion and the capability to perform photon counting.
Because the only genetic aberration in these animals is the reduction of SMN activity, the observed phenotypes must be due to SMN activity reaching a threshold for neuromuscular functionality.
The matched sequences with the exceeding the user defined functionality value threshold are kept.
Thus, by allowing for variable coding, the information threshold for obtaining certain functionality can already be alleviated by using a more compact coding.
However, 11 out of the 121 nonsynonymous RNMs and 42 out of the 283 nonsynonymous SNMs passed the functionality score threshold of SIFT, had comparable Conservation Index with disease-causing mutations (i.e., within 1SD from the mean ConSurf values of disease-causing mutations), and passed at least one additional test (MutPred or Panther), similarly to the disease-causing mutations.
Three SNPs (rs1800625, rs1800624 and rs2070600) are selected from 10 SNPs with a minor allele frequency of more than or equal to 5% based on LD threshold and their possible functionalities.
Due to the negative differential resistance exhibited by resonant tunneling diode (RTD), RTD is suited to implement the threshold gates and increases the functionality of a single gate.
