Sentence examples for threshold for alteration from inspiring English sources

Consequently, we chose an individual-tumor alternative to a global threshold for alteration, the former being more sensitive to the detection of this sort of cryptic signal.

We hypothesized that nucleus pulposus cells would respond to compressive stress with different thresholds for alterations in catabolic and anabolic gene expression.

Additionally, sample-specific thresholds for alterations were computed for all other analyses.

Consequently, we found that even after segmentation, a dataset-wide log2 threshold for detecting alteration underperforms in such a noisy system (data not shown).

Thus, placental HCB transfer to the fetus may not reach the threshold for subclinical alteration in porphyrin excretion patterns.

We tentatively selected a two-fold (or greater/lesser) criteria (relative to control values) to be a conservative threshold for measuring alterations in gene expression.

A difference >2-fold or <0.5-fold in transcript abundance was chosen as the threshold value for alterations that are likely to be biologically significant.

A standard threshold for copy number alteration of >0.3 for amplification and < -0.3 for deletion was applied as previously described by [ 58- 60].

A standard threshold for copy number alteration of > 0.3 for amplification, and < -0.3 for deletion was applied as previously described [ 17- 19].

In this study, we focussed on mosaic events of at least 2 Mb in size, a generally accepted threshold for large structural alterations (10), allowing a fair basis of comparison for the different chip designs we analysed, and concordant with a recent study that used an SNP chip design and algorithmic protocol similar to our own (11).

Regarding the former, we found at least four distinct causes that can obscure copy-number changes in a tumor and this motivates our departure from global thresholds for detecting alterations.