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The effect achieved a maximum inhibition of 60% of basal secretion rates, showing a threshold effective dose of 0.1 ng ml−1 compatible with reported plasma values of PTHrP.
The dose and plasma concentration necessary to inhibit 50% of STAT5 phosphorylation (threshold effective dose (TED50) and threshold effective concentration (TEC50)) were determined to be 12.7 mg/kg and 699.0 ng/ml (1.49 μℳ), respectively, at 30 min after dosing.
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In addition, we tried to identify the threshold biologically effective dose (BED) for rib fracture after SRT and risk factors for rib fracture.
For each antigen, positivity in the PBNA was defined as a serum dilution greater than or equal to the assay threshold of 40 effectiveective dose producing 50% response).
This might be because it is a sub-threshold (sub-effective) dose.
Beyond this threshold effective stress effects dominate.
The data were respectively expressed as cycle threshold (Ct) and log2 50% effective dose values.
First, the persistence of FGA prescription at higher doses than the recommended on international consensus [ 3- 6] may be related to the belief on "rapid neuroleptization" or impregnation for the management of an aggressive and agitated psychotic patient; and second, the use of low doses of these drugs reflects the preference for prescribing threshold or minimum effective doses.
"For most of these detected compounds, a person would have to drink at least tens of thousands of glasses of water a day to get one effective dose of the substance or to meet a toxicity threshold," the DEP said in a statement.
Most adverse effects are dose-related, which underlines the importance of achieving the lowest effective dose.
The effective dose for chemical water treatments to control plant pathogens was in some cases above documented phytotoxicity thresholds, and for most crops and technologies the phytotoxicity thresholds remain unknown.
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