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Post-RT OME was not an independent predictor of hearing threshold deterioration.
An independent t-test was used to determine the correlation between the possible predisposing factors and average hearing threshold deterioration.
The post-RT OME group treated with IMRT and a radiation dose <72 Gy might have had less severe hearing threshold deterioration.
We found no significant correlation between age and gender and post-RT HL data adjusted or not for age-related threshold deterioration.
In our study, the total dose of cisplatin was less than 600 mg/m, which might explain why the threshold deterioration was not correlated with chemotherapy.
After adjusting for age-related hearing threshold deterioration, HL owing to the treatment of NPC was present clinically at least 12 months after RT and involved all frequencies.
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In the 9-year follow-up after completing RT, without adjusting for age-related deterioration, the air conduction threshold deteriorated every year (p < 0.05), especially at 4 8 kHz).
Vertical red lines denote probability threshold before deterioration in performance.
Nevertheless, we were unable to develop a robust threshold for deterioration.
Glycemic threshold for deterioration of cognitive function measured by four-choice reaction time was unchanged, while the color-word Stroop test showed a degree of adaptation.
In contrast, the plasma glucose threshold for deterioration of cognitive function based on the color word interference component of the Stroop test changed from 2.6 ± 0.1 mmol/L at baseline to 3.0 ± 0.2 mmol/L in the post-RCT clamp (P = 0.045).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com