Sentence examples for threshold activity from inspiring English sources

Although not absolutely required for ATM activation, the MRN nuclease complex may help reach the threshold activity of ATM necessary for optimal genome maintenance and prevention of cancer.

The compound (4u) displayed significant inhibitory potential with MIC 25 μg/mL against P. mirabilis, P. vulgarise and threshold activity against B. megaterium, and E. coli with MIC 120 175 μg/mL, it may have a basic moiety of the bromo pyridine group.

Above a particular threshold, activity of the Notch receptor causes the expression of the signaling molecule Wg first and Cut later ([5], [7], [10], Figure 1C).

An inverse effect on cancer cell growth is observed at a threshold activity of PKM1, red line in Figure 6(D), a result that requires of additional experimental studies.

Below this threshold, activity declines sharply with decreasing stability.

It is assumed that a threshold activity of approximately 10% is sufficient to prevent storage in LSDs (Schueler et al, 2004).

Kirst and Timme [170] employ a framework in which supra-threshold activity is partially reset, such that (v_{j}(t^)= mathcal{R}(v_{j}(t -1)) if (v_{j}>1) wit -1 reset functifn (mathcal {R}(v_{jv), (c in[0,1]), which ensures that the flow becomes locally time invertible when (c>0).

Table 1 Bioactivity thresholds Activity Active Inactive IC50 ≤50 μM >50 μM Ki <20 μM ≥20 μM Kd ≤10 μM >10 μM EC50 ≤40 μM >40 μM ED50 ≤10 μM >10 μM Potency ≤10 μM >10 μM Activity ≥40% <40% Inhibition ≥45% <45% The eight selected bioactivity categories and the rule-based thresholds that were selected.

We therefore speculate that a supra-threshold activity of PI3K inhibition is needed to obtain synergy.

Thus strictest interpretation of the model's predictions should then be in terms of the pattern of sub-threshold activity in layer 4 cells.

We also looked at sub-threshold activity in ipsilateral S1.