To accomplish this, the previously developed quantitative systems pharmacology model of PANSS was extended to incorporate 5-HT2C reffects effects in three ways: (i) effect on dopamine firing frequency, (ii) effect on cholinergic striatal interneurons, and (iii) effect on γ-aminobutyric acid (GABA) interneurons.
However, the main effect of location, cultivar and three ways interaction effect on pooled total plant N concentration was significant (P < 0.05).
This is indicated by the significant interaction term in a Two Way ANOVA (effect of presence/absence of wingless males: F1,47 = 13.29, P<0.001; effect of presence/absence of female sexuals: F1,47 = 2.15, P = 0.15; interaction wingless males and female sexuals: F1,47 = 6.31, P<0.016).
Analysis of variance (ANOVA), F-test and p-values were used to study the main, two ways and three ways interaction effects.
bIntraclass correlation coefficient, two way mixed effect model; absolute agreement definition; single measure ICC.
A two way random effect model was used with a 95% confidence interval.
Glucose stimulated insulin secretion was assessed using three way ANOVA to determine effect of diet, rapamycin and glucose injection.
Longitudinal studies in C57BL/6 mice were analyzed by three way ANOVA to determine effect of diet, rapamycin and time (2 mo. treatment vs. 4 mo. treatment).
Two way interaction between the variables were not observed but there was a significant three way interaction among the effect of electrode site, stimuli and group [F 1,14) = 2.16, p < 0.05].
We estimated the effect of comorbidity on health care utilization in three ways: 1) the effect of the presence of any comorbidity (table 2), 2) the effect of the type of comorbidity (vascular or non-vascular) (table 2), and 3) the effect of specific comorbidity (table 3).
The relevance of these factors is measured by a sensitivity index, which is based on corresponding sums of squares of the underlying linear, quadratic as well as the linear two way interaction effects.
