Sentence examples for three major mutations from inspiring English sources

Holler et al. reported that the three major mutations associated with CD (R702W, G908R and 1007fs) are also associated with severe acute GVHD and bone marrow transplantation (BMT) related mortality [3].

Three major mutations have been reported for FQ resistance in streptococci at codon positions 81 in gyrA and 79 or 83 in parC (4 ).

Several Chinese studies have relied on the three major mutations in BRCA1 gene including 3478del5, 5589del8, and 1100delAT, with the first being only annotated in Chinese women [ 116, 117].

Three major mutations identified in transmissible strains are L26F, V27A, and S31N 2, 8, all of which are located on the transmembrane domain (residues 24 46) of the M2 protein.

Three major mutations are associated with sheep susceptibility or resistance to classic scrapie and BSE: at codons 136 (A or V), 154 (R or H), and 171 (R, Q, or H) (7 ).

By contrast, the carrier frequencies of the three major mutations that cause Leber hereditary optic neuropathy (LHON), m.3460G→A, m.11778G→A, and m.14484T→C, were equal.

Two major mutations (C282Y and H63D) were determined for each patient.

In Greek territory, two major mutations were described.

Two major mutations are known in the HFE gene: C282Y and H63D mutations.

The KRAS PCR Kit (DxS-QIAGEN) was used for detection of seven major mutations in KRAS codons 12 and 13.

Two major mutations were also found in KRAS, G12D (n = 1) and G13D (n = 3), well known in colorectal cancer to predict a resistance to EGFR antibodies 35.