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Values in percentage represent the fraction of common genes compared to the whole growth rate response (for the three first lines) or the whole stringent response (for the three last lines).
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We have generated two pharmacophores using three first line and four second line M.tb drugs, (see Methods section) and then scanned these pharmacophores in our datasets.
The pharmacophore features were generated for the three first line (rifampicin, ethambutol and streptomycin) and four second line (ethionamide, cycloserine, kanamycin, amikacin) M.tb drugs using pharmagist software [28].
MRI brain may be useful when three first line preventive treatments fail [12].
For episodic migraine without aura that needs preventive treatment, some experts recommend brain MRI when three first line preventive treatments fail [2, 3].
In Table 3, the two first lines consider WLAN (Wireless Local Area Network) and WMAN Wireless Metropolitan Area Networkk) systems.
The two first lines were involved in all of these deaths.
Susceptibility testing to pyrazinamide, streptomycin and the remaining three second line drugs terizidone, capreomycin, para-aminosalicylic acid— was not performed.
Resistance results to the three second-line drugs first tested are shown in Table 4.
Only eight (16%) EMB-resistant strains were also resistant to the other three first-line drugs.
The three second-line treatment alternatives recommended by the National Cancer Center Network (NCCN) were compared to determine the best therapy for reimbursement.
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CEO of Professional Science Editing for Scientists @ prosciediting.com