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The agency conducted two investigations and three examinations over the years.
Fitness was determined based on the duration of a maximal graded exercise treadmill test (Balke protocol) at up to three examinations over 20 years from 3,989 black and white men and women from the Coronary Artery Risk Development in Young Adults study.
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Children were allowed up to four examinations over time.
The SHFS included two examinations over an 8-year period (2001 2009).
Consistency of the serum glucose assay over examinations was established by reanalyzing 200 samples from each of the four examinations over a short time period and then recalibrating the original observations.
14 Participants in the present study were members of the baseline cohort of preschool children aged less than 5 at enrolment, who had been maximally exposed to the nutrient supplement protocol (five 200 000 IU of vitamin A v placebo) and the risk of acquiring a detectable, preschool ear infection during the period of the trial (five examinations over a 16 month period).
In the Whitehall II study of British civil servants, exposure to antidepressant medication was monitored by repeated clinical interviews and undiagnosed diabetes was screened using an oral glucose tolerance test in four examinations over an 18 year follow-up period [ 11].
A way to overcome the ethical and methodological difficulties of using patients for as many as three examinations is to spread them out over several days, as in the studies of Ljungquist et al. [ 4] and Horneij et al. [ 13].
Grades were compared for three identical examinations over the course of the Fall 2015 and Fall 2016 semesters.
The cognitive test battery, administered at three clinical examinations over 10 years (phases 5, 7, and 9), was chosen to provide a comprehensive assessment of cognitive function and be appropriate for this population composed of individuals younger than in most studies on cognitive ageing.
In this prospective cohort study of almost 6000 middle-aged men and women, we found antidepressant use at four clinical examinations over an 18-year period to be associated with physician-diagnosed diabetes.
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