The WHO sent its entire yellow fever vaccine arsenal ― 6 million doses in total, according to STAT ― to battle Angola's outbreak.
Treatments were prepared fresh daily and repeated daily for a further 3 days (i.e., four doses in total).
By default, 375 mg/m rituximab are applicated as a weekly intravenous infusion for six to eight doses in total either concurrently or sequentially to PA.
Animals were randomized into three groups of six and dosed in the morning with HSA-hNEPv in PBS (pH 7.2) at twice weekly intervals for 1 month (eight doses in total) by slow intravenous infusion (over 15 min) at dose levels of 0 (vehicle control), 5 and 50 mg/kg and a dose volume of 5 ml/kg bodyweight.
Animals were randomized into four groups of three and dosed with HSA-hNepv in PBS (pH 7.2) in the morning at twice weekly intervals for a month (nine doses in total) by slow intravenous bolus injection (over 2 min) at dose levels of 0 (vehicle control), 5, 50 and 143 mg/kg and a dose volume of 3 ml/kg bodyweight.
Drug and vehicle treatments were done by oral gavage twice daily, with each group receiving six doses in total over 4 days (1 dose late on day 0, 2 doses on days 1 and 2 and 1 dose early on day 3).
Forty-one male and 41 female Sprague-Dawley rats (Charles River), aged ∼8 10 weeks, were dosed in the morning with human serum albumin-human neprilysin variant fusion protein (HSA-hNepv) in PBS (pH 7.2) at twice weekly intervals (nine doses in total) by slow intravenous bolus injection (over 2 min) at dose levels of 0 (vehicle control), 5, 50 and 143 mg/kg.
But once the FDA approved the drug for all SMA patients and Biogen and Ionis Pharmaceuticals set the price, cost became the biggest concern, especially because treatment is ongoing: Patients receive six doses in the first year — at a total cost of $750,000 — and three doses in subsequent years — for a total annual cost of $375,000.
Complete tolerance occurred already within 24 h of the first dose (a total of four doses) in the middle cerebral artery.
We used rituximab at 375 mg/m, IV, weekly for a total of four doses in 18 adult patients.
