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Conceptually, the three core scales formed the QoLISSY-QoL total score, with the three domains (Coping, height-related Beliefs, Treatment) serving as additional determinant modules.
The QoLISSY instrument consists of three core scales which cover Physical (six items), Social (eight items) and Emotional (eight items) aspects of functioning and well-being in child- and parent-report.
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Construct validity was assessed by confirmatory factor analysis of the three core QoL scales and was subsequently repeated for the three mediator domains (not reported here).
Thus, in the absence of a "perfect" assessment, we would recommend continuing use of the three core assessment scales: the mRS as an outcome if the study is describing global disability, the NIHSS for studies looking at neurological impairment, and the BI for studies looking at basic ADL.
Significant positive correlations between the three QoLISSY core scales and the KIDSCREEN Index suggest convergent validity, however, with a percentage of shared variance below 10% for child-reported values.
The PedsQL™ 4.0 is a standard form 23-item quality of life questionnaire consisting of four Generic Core Scales: Physical Functioning, Emotional Functioning, Social Functioning and School Functioning [ 50].
The QoLISSY instrument showed high inter-correlations of the three cores QoL scales while the association with the Coping subscale was lower (Table 5).
The PedsQL™ 4.0 Generic core scales show two global scores: psychosocial health (encompassing emotional, social, and school) and total score (physical, emotional, social, and school).
The PedsQL™ Generic Core Scales [ 15] has four scales: Physical Functioning (eight items), Emotional Functioning (five items), Social Functioning (five items), and School Functioning (five items).
Boyer et al. have identified the bound genes of the three core TFs in vivo by genome-scale location analysis [ 2].
Rasch RSM analysis on the four subscales of PedsQL™ 4.0 Generic Core Scales show that person reliability and separation are low, while item reliability and separation are high.
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