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Metabolite corrected plasma curves were best described with a three compartment model.
Initially we employed a three compartment model, involving the arteries, veins and left ventricle.
A three compartment model best described the FA course.
Mitoxantrone pharmacokinetics were best described by an open two- (six kinetics) or an open three compartment model (11 kinetics).
With improved image processing and membrane markers, subsequent studies will be aimed at progressing to a three compartment model.
Seven used a two compartment model, 11 12 14 15 17 18 21 one used a three compartment model, 31 one used both one and two compartment model 17 and five used a non-compartment model.
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A kinetic model for measuring [C]AMT uptake was developed using a three-compartment model (or two-tissue compartment model) with irreversible tracer trapping, the compartments being plasma, brain and irreversibly trapped tracer [ 7, 51].
Therefore, we considered a classical two- or three-compartment model with elimination from the first compartment physiologically incorrect.
The choice of structural model (e.g. one-, two- or three-compartment model for PK and an Emax model for PD) is to be based upon the best a priori information about the drug to be studied [ 40].
F-FDG net uptake rate was calculated by fitting the F-FDG kinetics with the Sokoloff three-compartment model for three isogravitational ROIs defined along the vertical axis: dependent, middle and nondependent [ 13].
The presented data support the applicability of the three-compartment model with two tissue compartments connected in parallel for description of the kinetics of the AT1R selective radioligand [C]KR31173 in the kidneys.
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