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The mean weights were determined for three compacts of each formulation, and the percentage of swelling (S%) was calculated according to the following relationship (Efentakis et al. 1997): (2) S % = W s − W d W d × 100 where Wd and Ws are the dry and swollen compact weights, respectively, at immersion time t in the test liquid.
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This preliminary structure, as well as sequence-based secondary structure and disorder prediction confirmed the presence of three compact α/β domains separated by flexible linkers.
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