Sentence examples for three central domains from inspiring English sources

This led to an estimate of the average cleavage density over the three central domains that was 86 ± 4% of that on the euchromatic arms.

In this study, primary fibroblasts from individuals carrying pathogenic mutations in the three central domains of LRRK2 were assessed for alterations in the autophagy/lysosomal pathway using a combination of biochemical and cellular approaches.

The impact of mutations in the three central domains of LRRK2 upon autophagy and lysosomal function were assessed in patient derived fibroblasts harboring LRRK2 mutations – the R1441G mutation in the ROC/GTPase domain, the Y1699C mutation in the COR domain and the G2019S mutation in the kinase domain – and age/sex matches control cells [25].

Since 2004, a number of cellular processes have been linked to the function of LRRK2, however no cellular phenotype has been found to be altered in the same way by penetrant mutations in each of the three central domains of LRRK2.

Filaggrin-2 is composed of an NH2-terminal domain homologous to S100 proteins and by two central domains formed by repeated subunits.

Domain truncation experiments reveal that FIR interacts with TFIIH via the N-terminal 55 amino acids (Liu et al, 2000), with FBP via two central RRM domains and with FUSE via the same RRM domains (Chung et al, 2006).

The present cluster analysis confirms the existence of these four domains (central domain, central domain + central ring, central ring and external ring).

The normative approach quickly takes one into the central domains of epistemology, raising questions such as: "Is knowledge identical with justified true belief?," "Is the difference between knowledge and belief merely a matter of probability?," and "What is justification?" Philosophers have disagreed sharply about the complex relationship between the concepts of knowledge and certainty.

The interview protocols used a semi-structured format organized around four central concept domains: the meaning of permanency, permanency goals and options, the permanency planning process, and post-permanency outcomes.

School and home are two central life domains for the socialization of children and adolescents.

A 216-amino-acid protein (hereafter referred to as FIR1+2) consisting of the two central RRM domains of human FIR (accession code AF217197), residues 101 299, preceded by a His-tag, was expressed and purified for biochemical, biophysical and crystallization experiments (see Materials and methods).