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But if Erbitux was shown to work on its own, it would undermine the rationale behind the main study, threatening approval of the drug.
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Since ethical issues surrounding randomization of the individual pregnant woman for a Q fever screening or non-screening strategy could seriously threaten approval by an ethics committee, we designed a clustered randomized controlled trial in which primary care midwife centres are randomized to recruit either pregnant women for the control group or for the intervention group.
But it also contains an array of new restrictions on player movement and team payrolls, all of which the union opposes, and which still threaten the approval of any deal.
The failure to reach a deal underlines the extent of political deadlock in Slovakia that could threaten final approval of the expanded 440 billion euro, or $600 billion, bailout fund.
Our dismal production controls were threatening the UL approval project.
And now Republicans in the House are threatening to deny that approval unless President Obama makes major policy concessions.
Congressional Republicans (and some Democrats) are threatening to hold up approval of free-trade agreements with South Korea, Colombia and Panama if President Obama keeps insisting on renewing expanded benefits under Trade Adjustment Assistance, the main aid program for American workers harmed by foreign trade.
With approval threatened, the firm hired a Canadian company to test a scale model in a wind tunnel, delaying the design process by another year.
But the Nigerians, insisting change in ownership required government approval, threatened to repossess the assets.
The US delegation was unwilling to increase their offered target of 17% emission reduction compared to 2005, since this would have threatened its later approval by the US senate.
7 In 1992, Congress authorized the "accelerated approval" pathway, allowing drugs treating serious or life threatening illnesses to be approved on the basis of surrogate endpoints reasonably likely to predict patient benefit.
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