The properties of eccentric muscle actions which lead to this protective effect remain to be elucidated but are thought to include cellular, mechanical and neural adaptations.
Although the exact mechanisms by which LOX activity promotes invasiveness remain to be elucidated, they are thought to involve increased cell-matrix adhesion, increased integrin clustering and FAK activation (Payne et al., 2005; Erler et al., 2006).
Although the function of vaults in both normal and cancer cells is not fully elucidated, they are thought to be involved in intracellular redistribution of drugs, reducing exposure of nuclear targets from cytotoxic agents (Chugani et al, 1993; Kitazono et al, 1999).
Cranberries' mechanism of action has not been fully elucidated, though it is thought to be attributed to two components, proanthocyanidins and fructose [ 20].
Even though ovarian CSCs have not been fully elucidated, these cells are thought to play a crucial role in disseminated metastasis and relapse at peritoneal metastatic sites.
Although the underlying mechanisms of MPM have not been fully elucidated, inherited predisposition is thought to be an important factor [ 23].
The pathogenesis of NCM has not been fully elucidated but it is thought to represent a congenital error during early embryonic migration of melanocytes.
Though the mechanisms of action involving HMB-FA have not fully been elucidated, it is currently thought to work through improving protein turnover and skeletal muscle regeneration (Wilson et al. 2008; Zanchi et al. 2011).
15 Since previous relationships between KCNQ1 mutation and deafness in the Jervell and Lange-Nielsen syndrome were elucidated, KCNQ4 has been thought to be a candidate gene for individuals with slowly progressive hearing loss.
Originally thought to be three separate pathways, we are just beginning to elucidate the network of interactions and regulations that impact the outcome following DNA damage.
