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Growth factors are believed to establish auto-, para- and juxtacrine loops that are thought to augment and amplify initial steroid hormone signals.
This effect is attributed to warm-up angina, which is thought to augment the innate resistance of the myocardium to an ischaemic insult [ 51, 52].
Inhibition of HDACs is thought to augment gene transcription, as the histones cannot be changed to their highly condensed, hypoacetylated form (Kim et al, 2003).
The lysine residues in both transcription factors are subjected to acetyl group addition, which is thought to augment assembly of the transcriptional machinery and to enhance gene transcription [ 35].
In the context of suppressing primary tumor growth by targeting the tumor vasculature, concurrent Ang1 inhibition was thought to augment the activity of Ang2-specific inhibition (Falcon et al, 2009; Coxon et al, 2010), but metastatic disease was not modeled in these preclinical studies.
Similar(55)
Both of these activities cross fertilized with and were thought to have augmented the DAMP.
Both a study 41 and a recent review 42 support the use of platelet gels (patient's own plasma and platelets used as a low concentration fibrinogen source combined with a free standing thrombin to create a fibrin sealant like material thought to have augmented value as result of growth factors in platelets) in rhytidectomy.
Activation of host plasminogen to plasmin, a potent serine protease that can bind to the surface of numerous bacterial pathogens, is a mechanism thought likely to augment a variety of streptococcal infections.
The monoclonal antibody ipilimumab, approved in over 40 countries to treat advanced melanoma and currently under phase 2 and 3 investigation in prostate cancer, is thought to act by augmenting immune responses to tumors through blockade of cytotoxic T-lymphocyte antigen 4, an inhibitory immune checkpoint molecule.
Intraaortic balloon counterpulsation (IABP) has been used for RV failure after CPB [ 356] and transplantation [ 357], thought to improve CO by augmenting left coronary flow rather than by direct RV effects [ 358].
AGR2 is thought to promote tumor formation by augmenting cell viability, anchorage-independent growth, and invasive properties of the biliary tract cancer cells.
Related(20)
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