SMARCA2 is a member of the SWI/SNF family of proteins with helicase and ATPase activities and thought to activate transcription altering chromatin structure in specific sites [ 40].
Acetyl-phosphate is thought to activate expression of invasion genes, which can also be activated via a sensory kinase BarA.
JNJ-26854165 (Serdemetan) is a p53 activating tryptamine derivative that was initially thought to activate wild-type p53 by functioning as a E3 ubiquitin ligase inhibitor [ 7].
Recent data suggests that intracellular leucine levels are detected by a leucyl-tRNA synthetase (LRS), which is thought to activate the Rag GTPase complex, binding to Raptor and activating mTORC1 signaling on the surface of lysosomes.
DCs are thought to activate B cells and trigger their class switching via the production of various cytokines.
Mechanical stimuli from application of these short pulsed waves are thought to activate new collagen growth, stimulate angiogenesis around fat cells, and activate lipases, resulting in tightening and improved appearance of cellulite.
The binding of E to these cell-surface forms of E-receptors is thought to activate several second messenger systems via the activation of G-proteins, resulting in the activation of different protein kinases.
As activating mutations of RAS genes and FGFR3 are mutually exclusive events in UC and are thought to activate the same signalling pathways (Jebar et al, 2005), a RAS mutation may confer resistance to FGFR inhibition.
These residues are thought to activate the catalytic water of hydrolysis at the active sites and are therefore at a crucial position in the catalytic sites.
ATP is thought to activate P2Y (seven transmembrane-span G-protein-coupled) receptors at sub-micromolar concentrations, whereas much higher ATP levels are needed to activate P2X (ligand-gated ion channel) receptors [ 20].
