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Though minute amounts of these metals (e.g. Cu, Ni, Zn) are required in several cellular processes, excessive heavy metal ion concentrations can also exert deleterious effects by catalyzing oxidation of lipid membrane, damaging nucleic acids, and producing free radicals (Cánovas et al. 2003; Thounaojam et al. 2012; Wang et al. 2004).
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