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Inhibitors of efflux pumps, for example, have been discovered, and though challenging to implement in organisms with multiple redundant systems, are worthy of continued investigation.
Though challenging to implement at a reasonable cost, such services may provide a more effective research environment that will improve patient safety, increase economic and medical efficiency, and provide a more standardized and regulatory-compliant process for conducting research.
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An alternative to treating variants differently according to such factors as their rarity and predicted function would be to adopt a more post hoc, model-fitting approach which would attempt to make inferences about the nature and magnitude of the effect of each variant, though again it might be challenging to implement this in practice.
"The recommendations are sometimes challenging to implement," Mr. Bass said.
Nevertheless, she says, personalized learning is "extremely challenging to implement well".
But nearly any solution will be challenging to implement during a war.
Trigger warnings are also challenging to implement, because identifying potential triggers isn't easy.
While being yourself is a simple concept, it is challenging to implement.
The National Cancer Institute said that the information system was "in its infancy" and would be a challenge to implement.
Still, it may be a challenge to implement this approach, notes Adam Drewnowski of the University of Washington, Seattle.
There are three major challenges to implementing a VMI framework.
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