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Our conclusion is that we cannot find histology subtype specific prognostic signature, which does not imply there is no common prognostic genes for those two subtypes.
Similarly, a signature that can distinguish between two subtypes of cancer is useful only if those two subtypes differ in some clinically relevant way, such as in survival time or response to therapy, since otherwise the information about cancer subtype provided by the molecular signature may not serve a practical purpose.
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We also have shown that those three subtypes share both overexpressed and underexpressed sets of genes determining that most enriched pathways for each subtype of carcinoma are different and these differences, could be related to the aggressiveness and invasiveness.
Different taxonomies have been used to define these two subtypes.
In this study, these two subtypes had significantly differing BCSS.
Perhaps this is indicative of signalling between these two subtypes.
However, the number of reconstructed primary dendrites (and thereby dendritic trees) per motoneuron was similar between immediate and delayed firing motoneurons and we could therefore readily compare those radial dendrites in the two subtypes.
Thus these two subtype proposals are not mutually exclusive.
However, the two subtypes function differently in the pathogenesis of vascular diseases, such as MI/R injury156, hypertrophy and fibrosis157.
These were used to discriminate between the two subtypes.
We would classify the two subtypes as follows.
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