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Antagomirs are modified antisense oligonucleotides (morpholinos) artificially synthesized that thoroughly target the mature miRNA sequence, thereby increasing the amount of mRNA target of that specific miRNA [ 61, 62, 65].
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The other half of the task, of course, is making sure that you land the candidate you've so carefully and thoroughly targeted.
Whatever you choose, be sure to research thoroughly and target firms that are specific to your sector.
The Mycobacterium tuberculosis (M. tuberculosis) enoyl-acyl carrier protein reductase (mtInhA) is an attractive enzyme and a thoroughly studied target for tuberculosis therapy.
We searched all leaf litter, rocks, logs, vegetation below 0.5 m and the top 50 mm of soil, covering the entire area thoroughly for target taxa.
Dihydrofolate reductase (DHFR), which catalyzes the last step, is one of the most thoroughly explored targets of this pathway, but there are no DHFR inhibitors used for tuberculosis treatment.
To more thoroughly block targeted ads, you can specifically prevent Apple's own iAd system from tracking your behavior and presenting ads based on that activity.
Appropriate subject headings and relevant keywords were used to thoroughly describe the target population of people's musculoskeletal health/signs and symptoms with special reference to pain and smoking/not smoking; unhealthy nutrition/healthy nutrition; sedentary behaviour/physical activity and exercise; sleep deprivation/healthy sleep; and anxiety and stress/good mental health.
"Additionally, reasonable measures were undertaken to avoid the death or injury of civilians during the strike by thoroughly reviewing the targets prior to engagement, relying on accurate assessments of the targets, and engaging the targets when the risk to non-combatants was minimized.
All the pigments result from a combination of enzyme activity and simple chemical reactions, so you get the most intense color by puréeing the garlic and onion to mix enzymes thoroughly with their targets, then holding the purée on low heat to speed the enzymes without denaturing them, and finally heating it to a simmer to speed the nonenzymatic reactions.
BMW examined the market thoroughly and is targeting hip, young, urban professionals with the i3's forward design, a smaller urban-friendly size, and the brand's proven appeal with a younger demographic.
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CEO of Professional Science Editing for Scientists @ prosciediting.com