Compared to using the raw data as input for the LDA, this procedure adjusts the relative importance of examined projections by taking into account how thoroughly the underlying predictive variable space was sampled.
The statistically significant predictive models were thoroughly validated using an external validation set whose activity was previously unknown.
The estimation of fracture risk using clinical risk factors (CRFs) is of primary concern in osteoporosis management, but only some risk factors have been thoroughly evaluated and incorporated in predictive models.
For research purposes, longitudinal designs should be employed in order to assess predictive validity more thoroughly.
However, for their use in the clinical practice, it is necessary that accuracy and predictive ability is thoroughly evaluated, since they may influence not only the adoption of a particular model but also its threshold.
Although their prognostic and predictive applications have been thoroughly examined in patients with breast cancer, the exact nature of ITC in gastric cancer remains to be determined.
The utility and benefits of QsarDB have been thoroughly tested by solving everyday QSAR and predictive modeling problems, with examples in the field of predictive toxicology, and can be applied for a wide variety of other endpoints.
The actual predictive powers of both models were thoroughly validated with an external test set, which gave satisfactory predictive r2 values of 0.89 and 0.90, respectively.
Rather, they need to be tweaked so thoroughly and so frequently that they lose their predictive power, instead always playing catch-up as new observations come in.
Furthermore, the current study prospectively tested a large number of previously described prognostic or predictive markers in medulloblastoma in a thoroughly controlled clinical trial cohort to prioritize markers to be considered for the next generation of clinical trials.
