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We agree that a more thorough discussion of the transcription factor changes observed at 1 hour is warranted.
A thorough search of the Plant Transcription Factor Database (http://planttfdb.cbi.pku.edu.cn) indicated that the earliest evolutionary occurrences of group III genes were those found in ferns (Selaginella moellendorffii).
The authors suggested that other pro-apoptotic pathways may also be activated and a more thorough study of p53-targeted transcription pathways was needed.
The only exception to this weighting rule is the data set from Rey et al. [ 15], which is given a weight of three, since it is a particularly detailed and thorough study of a central transcription factor (BMAL1).
The pro-death properties of Akt were shown to be mediated by its ability to induce ROS production by increasing oxygen consumption, thereby stimulating oxidative metabolism as well as by repressing the expression of antioxidant genes thorough the inactivation of FoxO transcription factors.
One quirk that has compounded a thorough and careful analysis of this transcription factor is the myriad naturally occurring isoforms of p63.
38 Open coding, which involved thorough familiarisation and annotation of transcript data, occurred over a 2-month period in two phases: (1) immediately after interview transcription; (2) 4 weeks after the last interview transcription.
This meant that no verbatim transcription was possible, precluding a thorough analysis of the spoken texts.
However, a thorough understanding of the relationship between m6A and transcription and/or splicing awaits future investigations.
Furthermore, Kuwabara et al. demonstrated that the NeuroD1 promoter could bind to Sox2 and TCF/LEF, the major downstream transcription factor of the Wnt/ β-catenin pathway thorough in silico analyses of NeuroD1 promoter.
Clearly, our results emphasize the relevance of combining detailed proteomic and transcriptomic studies for a thorough characterization of the venom toxin repertoire and the factors regulating transcription and translation.
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CEO of Professional Science Editing for Scientists @ prosciediting.com