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In the setting of neoadjuvant clinical trials, histopathologists are a vital part of the trial as thorough specimen handling and accurate histological reporting is essential to correctly assess the primary end point (Sahoo and Lester, 2009).
As pCR is the primary end point in neoadjuvant trials, the histopathologist assumes a pivotal role as thorough specimen handling and accurate reporting of results is vital to correctly assigning patient outcome.
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A thorough understanding of the specimen attributes that could affect a molecular assay are a key component of test optimization and validation.
Response to radiotherapy was evaluated from the excised bladders as either complete response (CR)–absence of residual malignant cells in the cystectomy specimen upon thorough histopathological examination–, or incomplete response (IR)–presence of residual malignancy in cystectomy specimen.
In the current cohort, one BRCA1 mutation carrier presented with metastatic disease 3.5 years after PM (no primary BC found), suggesting the presence of an occult primary tumor that was never found, despite a thorough reexamination of the specimen at the presentation of the metastatic disease.
Although similar techniques were used and the measuring apparatus appears analogous, this may represent a more thorough dissection of our specimens.
Since the 1990s, new discoveries and more thorough study of old specimens have shown that crests are far more widespread among pterosaurs than previously thought, due mainly to the fact that they were frequently extended by or composed completely of keratin, which does not fossilize as often as bone.
All surgical specimens underwent thorough pathological examination.
Despite thorough training, adequate sputum specimens can be obtained in only 50% of CAP.
Missing quadrate material in the holotype specimen prevented a thorough assessment of character (7) in the original diagnosis of Acrocanthosaurus atokensis.
However, to exploit the full potential of the multiple-specimen approach, a thorough understanding of its theoretical foundation, and a detailed experimental verification of its implicit assumptions is required.
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