The intimate relationship established between Fc glycosylation of the mechanisms associated with the clinical activity of therapeutic antibodies makes the thorough analysis and characterization of the glycosylation-specific CQA critical to the appropriate assessment of the impact that changes observed in specific glycovariants may have on safety and/or efficacy.
But is this an appropriate assessment?
Siegel tells this story with thorough, appropriate emphasis on the human element.
Conventional THAs are safer and easier, and should, therefore, be performed whenever possible even when hips have been classified as Crowe group IV; a thorough preoperative assessment is necessary to determine an appropriate surgical course.
Therefore it cannot be used as a clinical diagnostic tool, but as a referral tool that medical staff can use to identify such risks and refer patients to the appropriate mental and social health services for a thorough diagnostic assessment.
It was critical in the design phase to conduct a thorough needs assessment at the organisational, group and individual levels to determine appropriate design of the training and aligning the goals with the organisational strategies (Robertson 2002).
As in other medical settings, clinicians perform a thorough pretreatment assessment followed by the development of a comprehensive, individualized treatment plan that includes the most appropriate products and procedures, ongoing assessment, and modification of the plan as needed.
It has commissioned the Health Protection Agency to undertake a thorough risk assessment and review of the situation.
State legislators, medical societies and health experts have called for a thorough health assessment.
They need to heighten their vigilance for physical illness by conducting a thorough, unbiased assessment.
Typically, thorough neurological assessment and evaluation of cognitive function are undertaken.
